Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

pks11 (P9WPF3) - Overview - Molecular Target Synopsis

Protein


pks11, Alpha-pyrone synthesis polyketide synthase-like Pks11
Enzyme Classification 2.3.1.-
UniProt P9WPF3

Also Known as PKS11_MYCTU, pks11

Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks11 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. Homodimer.

4JAO
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PKS11 REVEALS INTERMEDIATES IN THE SYNTHESIS OF METHYL-BRANCHED ALKYLPYRONES
RCSB/PDB
Inspect Structure
See all 3D Structures for pks11

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: pks11 is active in the following subcellular-locations: polyketide synthase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project pks11 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For pks11 there are:
6 structures (24 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis