Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

cpdA (P9WP65) - Overview - Molecular Target Synopsis

Protein


cpdA, 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Enzyme Classification 3.1.4.53
UniProt P9WP65

Also Known as CPDA_MYCTU, cpdA, icc

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Can also hydrolyze cGMP, p-nitrophenyl phosphate (pNPP), bis-(p-nitrophenyl phosphate) (bis(pNPP)), p-nitrophenyl phenylphosphonate (pNPPP) and 2',3'-cAMP. May play a role in pathogenicity, not only by hydrolyzing cAMP, but also by altering properties of the cell wall. Homodimer.

3IB7
CRYSTAL STRUCTURE OF FULL LENGTH RV0805
RCSB/PDB
Inspect Structure
See all 3D Structures for cpdA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
318P9WP65-1, P9WP64-1

Sub-cellular localization


UniProt: cpdA is active in the following subcellular-locations: cell membrane, cell wall, cytoplasm, secreted.
GO terms: cpdA is active in the following subcellular-locations: cell wall, cytoplasm, extracellular region, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project cpdA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For cpdA there are:
5 structures (5 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

cpdA is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3IB8_A).

(see details)
Molecular Target 3D Synopsis