Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

serA (P9WNX3) - Overview - Molecular Target Synopsis

Protein


serA, D-3-phosphoglycerate dehydrogenase
Enzyme Classification 1.1.1.95
UniProt P9WNX3

Also Known as SERA_MYCTU, serA

Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

3DC2
CRYSTAL STRUCTURE OF SERINE BOUND D-3-PHOSPHOGLYCERATE DEHYDROGENASE FROM MYCOBACTERIUM TUBERCULOSIS
RCSB/PDB
Inspect Structure
See all 3D Structures for serA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
528P9WNX3-1, P9WNX2-1, P0A545-1

Sub-cellular localization


GO terms: serA is active in the following subcellular-locations: cell wall, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project serA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For serA there are:
3 structures (6 chains) solved
3 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

serA is solved in complex with the approved drug(s):

TAR/TARTARIC ACID (1YGY_A, 1YGY_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


serA has been screened with compounds ( bioactivities). (see details)