Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ndkA (P9WJH7) - Overview - Molecular Target Synopsis

Protein


ndkA, Nucleoside diphosphate kinase
Enzyme Classification 2.7.4.6
UniProt P9WJH7

Also Known as NDK_MYCTU, ndkA, ndk

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Homohexamer.

4AND
CRYSTAL FORM II OF THE D93N MUTANT OF NUCLEOSIDE DIPHOSPHATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS
RCSB/PDB
Inspect Structure
See all 3D Structures for ndkA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: ndkA is active in the following subcellular-locations: cytoplasm.
GO terms: ndkA is active in the following subcellular-locations: cytoplasm, extracellular region, host cell nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ndkA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ndkA there are:
4 structures (15 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ndkA has been screened with compounds ( bioactivities). (see details)