Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

argF (P9WIT9) - Overview - Molecular Target Synopsis

Protein


argF, Ornithine carbamoyltransferase
Enzyme Classification 2.1.3.3
UniProt P9WIT9

Also Known as OTC_MYCTU, argF

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis. Homotrimer.

2P2G
CRYSTAL STRUCTURE OF ORNITHINE CARBAMOYLTRANSFERASE FROM MYCOBACTERIUM TUBERCULOSIS (RV1656): ORTHORHOMBIC FORM
RCSB/PDB
Inspect Structure
See all 3D Structures for argF

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: argF is active in the following subcellular-locations: cytoplasm.
GO terms: argF is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project argF has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For argF there are:
2 structures (9 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


argF has been screened with compounds ( bioactivities). (see details)