Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

adoK (P9WID5) - Overview - Molecular Target Synopsis

Protein


adoK, Adenosine kinase
Enzyme Classification 2.7.1.20
UniProt P9WID5

Also Known as ADOK_MYCTU, adoK, cbhK

Catalyzes the phosphorylation of adenosine to adenosine monophosphate (AMP) (PubMed:14594827, PubMed:16511094). Can also catalyze the phosphorylation of the adenosine analog 2-methyladenosine (methyl-Ado) to methyl-AMP, the first step in the metabolism of this compound to an active form that displays antitubercular activity. Is not active on guanosine, inosine, deoxyadenosine, cytidine, uridine, or thymidine. Prefers dGTP and GTP to ATP as phosphate donors in vitro (PubMed:14594827). Homodimer.

6C9P
MYCOBACTERIUM TUBERCULOSIS ADENOSINE KINASE BOUND TO 6- METHYLMERCAPTOPURINE RIBOSIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for adoK

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: adoK is active in the following subcellular-locations: plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project adoK has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For adoK there are:
13 structures (20 chains) solved
12 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

adoK is solved in complex with the approved drug(s):

ADN/ADENOSINE (2PKM_A).

(see details)
Molecular Target 3D Synopsis