Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ahcY (P9WGV3) - Overview - Molecular Target Synopsis

Protein


ahcY, Adenosylhomocysteinase
Enzyme Classification 3.3.1.1
UniProt P9WGV3

Also Known as SAHH_MYCTU, ahcY, sahH

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. Homotetramer.

2ZIZ
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS S-ADENOSYL-L- HOMOCYSTEINE HYDROLASE IN TERNARY COMPLEX WITH NAD AND 3- DEAZAADENOSINE
RCSB/PDB
Inspect Structure
See all 3D Structures for ahcY

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
495P9WGV3-1, A1KNQ0-1, C1AH22-1, P9WGV2-1, A5U7S2-1

Sub-cellular localization


UniProt: ahcY is active in the following subcellular-locations: cytoplasm.
GO terms: ahcY is active in the following subcellular-locations: cell wall, cytosol, extracellular region, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ahcY has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ahcY there are:
5 structures (20 chains) solved
5 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

ahcY is solved in complex with the approved drug(s):

ADN/ADENOSINE (3CE6_A, 3CE6_B, 3CE6_C, 3CE6_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ahcY has been screened with compounds ( bioactivities). (see details)