Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

trxA (P9WG67) - Overview - Molecular Target Synopsis

Protein


trxA, Thioredoxin
UniProt P9WG67

Also Known as THIO_MYCTU, trxA, trx, trxC

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

2L59
SOLUTION STRUCTURES OF OXIDIZED AND REDUCED THIOREDOXIN C FROM M. TB
RCSB/PDB
Inspect Structure
See all 3D Structures for trxA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
116P9WG67-1, P0A617-1, P9WG66-1

Sub-cellular localization


GO terms: trxA is active in the following subcellular-locations: cell wall, cytoplasm, cytosol, extracellular region, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project trxA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For trxA there are:
4 structures (7 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


trxA has been screened with compounds ( bioactivities). (see details)