Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

caaA (P98005) - Overview - Molecular Target Synopsis

Protein


caaA, Cytochrome c oxidase polypeptide I+III
Enzyme Classification 1.9.3.1
UniProt P98005

Also Known as COX13_THET8, caaA, ctaD

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer. Possibly a heterodimer of A-protein (contains: cytochrome c oxidase subunits I and III) and subunit II. The A-protein could also present a precursor form of subunits I and III.

2YEV
STRUCTURE OF CAA3-TYPE CYTOCHROME OXIDASE
RCSB/PDB
Inspect Structure
See all 3D Structures for caaA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
791P98005-1

Sub-cellular localization


UniProt: caaA is active in the following subcellular-locations: cell membrane.
GO terms: caaA is active in the following subcellular-locations: integral component of membrane, plasma membrane, respirasome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project caaA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For caaA there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


caaA has been screened with compounds ( bioactivities). (see details)