Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Neo1 (P97798) - Overview - Molecular Target Synopsis

Protein


Neo1, Neogenin
UniProt P97798

Also Known as NEO1_MOUSE, Neo1, Ngn

Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. Interacts with BMP2, BMP4, BMP6, and BMP7 (By similarity). Interacts with RGMA and RGMB. Interacts with MYO10.

4PLN
CRYSTAL STRUCTURE OF CHICKEN NETRIN-1 (LN-LE3) COMPLEXED WITH MOUSE NEOGENIN (FN4-5)
RCSB/PDB
Inspect Structure
See all 3D Structures for Neo1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1493P97798-1
1482P97798-4
1477P97798-3
1473P97798-2
1440P97798-5

Sub-cellular localization


UniProt: Neo1 is active in the following subcellular-locations: cell membrane.
GO terms: Neo1 is active in the following subcellular-locations: cell surface, Golgi apparatus, integral component of plasma membrane, intracellular vesicle, membrane, neuronal cell body, nucleoplasm, plasma membrane, plasma membrane protein complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Neo1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


Neo1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For Neo1 there are:
7 structures (15 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis