Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Faah (P97612) - Overview - Molecular Target Synopsis

Protein


Faah, Fatty-acid amide hydrolase 1
Enzyme Classification 3.5.1.99
UniProt P97612

Also Known as FAAH1_RAT, Faah, Faah1

Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. Homodimer.

6MRG
FAAH BOUND TO NON COVALENT INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for Faah

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
579P97612-1

Sub-cellular localization


UniProt: Faah is active in the following subcellular-locations: endoplasmic reticulum membrane, golgi apparatus membrane.
GO terms: Faah is active in the following subcellular-locations: endoplasmic reticulum membrane, Golgi membrane, integral component of membrane, organelle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Faah has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Faah there are:
21 structures (58 chains) solved
20 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Faah has been screened with 2320 compounds (3484 bioactivities), 998 compounds have bioactivities that show binding affinity of <= 500nM (1400 bioactivities). (see details)