Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Etv6 (P97360) - Overview - Molecular Target Synopsis

Protein


Etv6, Transcription factor ETV6
UniProt P97360

Also Known as ETV6_MOUSE, Etv6, Tel, Tel1

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9.

4MHG
CRYSTAL STRUCTURE OF ETV6 BOUND TO A SPECIFIC DNA SEQUENCE
RCSB/PDB
Inspect Structure
See all 3D Structures for Etv6

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
485P97360-1

Sub-cellular localization


UniProt: Etv6 is active in the following subcellular-locations: nucleus.
GO terms: Etv6 is active in the following subcellular-locations: cytosol, nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Etv6 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Etv6 there are:
4 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Etv6 has been screened with compounds ( bioactivities). (see details)