Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Mcl1 (P97287) - Overview - Molecular Target Synopsis

Protein


Mcl1, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
UniProt P97287

Also Known as MCL1_MOUSE, Mcl1

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity. Interacts with HIF3A isoform 2 (via C-terminus domain) (PubMed:21546903). Interacts with BAD, BOK, BIK, BAX, BAK1, and TPT1. Interacts with BBC3, BMF and PMAIP1 (PubMed:15550399, PubMed:18589438). Interacts with BOP. Interacts with BCL2L11; this interaction may sequester BCL2L11 and prevent its pro-apoptotic activity (PubMed:16543145, PubMed:27013495, PubMed:15550399). Interacts with GIMAP5 and HSPA8/HSC70; the interaction between HSPA8 and MCL1 is impaired in the absence of GIMAP5 (PubMed:21502331).

6DM8
UNDERSTANDING THE SPECIES SELECTIVITY OF MYELOID CELL LEUKEMIA-1 (MCL- 1) INHIBITORS
RCSB/PDB
Inspect Structure
See all 3D Structures for Mcl1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
331P97287-1
285P97287-2

Sub-cellular localization


UniProt: Mcl1 is active in the following subcellular-locations: cytoplasm, membrane, mitochondrion, nucleoplasm, nucleus.
GO terms: Mcl1 is active in the following subcellular-locations: Bcl-2 family protein complex, cytoplasm, cytosol, integral component of membrane, membrane, mitochondrial outer membrane, mitochondrion, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Mcl1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Mcl1 there are:
16 structures (25 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Mcl1 has been screened with 47 compounds (73 bioactivities), 5 compounds have bioactivities that show binding affinity of <= 500nM (5 bioactivities). (see details)