Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

vapC5 (P96917) - Overview - Molecular Target Synopsis

Protein


vapC5, Ribonuclease VapC5
Enzyme Classification 3.1.-.-
UniProt P96917

Also Known as VAPC5_MYCTU, vapC5

Probable toxic component of a type II toxin-antitoxin (TA) system. The cognate antitoxin is VapB5. Has limited RNase activity on substrates; activity is seen with a VapC5-VapB5 complex. Forms a complex with VapB5.

3DBO
CRYSTAL STRUCTURE OF A MEMBER OF THE VAPBC FAMILY OF TOXIN-ANTITOXIN SYSTEMS, VAPBC-5, FROM MYCOBACTERIUM TUBERCULOSIS
RCSB/PDB
Inspect Structure
See all 3D Structures for vapC5

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
135P96917-1

Sub-cellular localization


UniProt: vapC5 is active in the following subcellular-locations: secreted.
GO terms: vapC5 is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project vapC5 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For vapC5 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis