Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ppsC (P96202) - Overview - Molecular Target Synopsis

Protein


ppsC, Phthiocerol synthesis polyketide synthase type I PpsC
Enzyme Classification 2.3.1.41
UniProt P96202

Also Known as PPSC_MYCTU, ppsC

Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. Homodimer.

5L84
STRUCTURE OF THE H959F VARIANT OF THE PPSC DEHYDRATASE DOMAIN FROM MYCOBACTERIUM TUBERCULOSIS
RCSB/PDB
Inspect Structure
See all 3D Structures for ppsC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
2188P96202-1, Q7TXL8-1

Sub-cellular localization


GO terms: ppsC is active in the following subcellular-locations: cytosol, plasma membrane, polyketide synthase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ppsC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ppsC there are:
6 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis