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rpoD (P95989) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed5
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria5


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3HKZ_D DNA-directed RNA polymerase subunit D Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 62.8 33.8 Yes No
2 empty 2.09 58.3 27.5 No No
3 empty 1.08 65 19.8 No No
4 empty 1.99 65.4 18.8 No No
5 empty 1.7 60.2 16.1 No No
6 empty 2.16 60.7 14.9 No No
7 empty 1.27 72 11.1 No No
8 empty 2.62 56.2 14.5 No No
9 empty 2.44 63.4 10.2 No No
10 empty 1.59 77.6 8.6 No No
2PMZ_D DNA-directed RNA polymerase subunit D Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.58 62.5 47 Yes No
2 empty 1.97 59.5 24.7 No No
3 empty 1.93 66 18.9 No No
4 empty 1.97 57.8 13.8 No No
5 empty 1.26 76.9 13 No No
6 empty 2.66 56.7 11.9 No No
7 empty 2.59 67.3 10.1 No No
8 empty 2.84 69.1 10.7 No No
9 empty 1.88 76.5 7.9 No No
10 empty 2.52 65.1 11.6 No No
3HKZ_O DNA-directed RNA polymerase subunit D Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 62.4 34.7 Yes No
2 empty 1.92 57.7 25.9 No No
3 empty 1.18 66.6 16.3 No No
4 empty 1.99 63.6 20.8 No No
5 empty 1.8 59.9 16.7 No No
6 empty 1.97 58.2 11.2 No No
7 empty 1.29 66.3 14.4 No No
8 empty 2.63 57 10 No No
9 empty 2.47 59.6 11.7 No No
10 empty 2.38 70.2 9 No No
2PMZ_S DNA-directed RNA polymerase subunit D Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 59.5 34.6 Yes No
2 empty 1.98 60.3 26.3 No No
3 empty 1.21 68.1 19.5 No No
4 empty 1.93 64.6 19.8 No No
5 empty 1.86 57 15.4 No No
6 empty 1.99 59.6 14.1 No No
7 empty 1.27 73.9 13.6 No No
8 empty 2.61 56.7 11.8 No No
9 empty 2.55 61.1 11.7 No No
10 empty 2.37 68 8.7 No No
2PA8_D DNA-directed RNA polymerase subunit D Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 62.6 47.3 Yes No
2 empty 2.1 59.3 24.1 No No
3 empty 2.05 65.8 19.6 No No
4 empty 2.34 56.2 11.8 No No
5 empty 2.49 55.3 14.1 No No
6 empty 2.36 62.8 12.6 No No
7 empty 2.26 55.6 16.1 No No
8 empty 2.61 65.2 9.5 No No
9 empty 1.91 61.4 7.7 No No
10 empty 2.98 79.4 4.7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed9
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria6

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2PA8_D (3170603) DNA-directed RNA polymerase subunit D PFAM, PFAM, PFAM RNA_pol_L 1.7Å Yes No
2PA8_D (3170603) DNA-directed RNA polymerase subunit D PFAM, PFAM, PFAM RNA_pol_L 1.7Å Yes No
2PA8_D (3170603) DNA-directed RNA polymerase subunit D PFAM, PFAM, PFAM RNA_pol_L 1.7Å Yes No
2PA8_D (3170604) DNA-directed RNA polymerase subunit D Insert subdomain of RNA polymerase alpha subunit, Insert subdomain of RNA polymerase alpha subunit, UNMATCHED 1.7Å Yes No
2PA8_D (3170605) DNA-directed RNA polymerase subunit D beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 1.7Å No No
2PMZ_D (3170937) DNA-directed RNA polymerase subunit D PFAM, PFAM, PFAM RNA_pol_L 3.4Å Yes No
2PMZ_D (3170937) DNA-directed RNA polymerase subunit D PFAM, PFAM, PFAM RNA_pol_L 3.4Å Yes No
2PMZ_D (3170939) DNA-directed RNA polymerase subunit D beta and beta-prime subunits of DNA dependent RNA-polymerase, beta and beta-prime subunits of DNA dependent RNA-polymerase, RNA-polymerase beta-prime 3.4Å No No
2PMZ_D (3170938) DNA-directed RNA polymerase subunit D Insert subdomain of RNA polymerase alpha subunit, Insert subdomain of RNA polymerase alpha subunit, UNMATCHED 3.4Å Yes No
2PMZ_D (3170937) DNA-directed RNA polymerase subunit D PFAM, PFAM, PFAM RNA_pol_L 3.4Å Yes No
3HKZ_D (3460158) DNA-directed RNA polymerase subunit D UNMATCHED, UNMATCHED, UNMATCHED 3HKZ 3.4Å Yes No
3HKZ_D (3460159) DNA-directed RNA polymerase subunit D Insert subdomain of RNA polymerase alpha subunit, Insert subdomain of RNA polymerase alpha subunit, UNMATCHED 3.4Å Yes No
3HKZ_D (3460160) DNA-directed RNA polymerase subunit D Cytochrome c, Cytochrome c, N-terminal (heme c) domain of cytochrome cd1-nitrite reductase 3.4Å No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score