Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Trxr-1 (P91938) - Overview - Molecular Target Synopsis

Protein


Trxr-1, Thioredoxin reductase 1, mitochondrial
Enzyme Classification 1.8.1.9
UniProt P91938

Also Known as TRXR1_DROME, Trxr-1, GR

Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms. Homodimer.

3DGH
CRYSTAL STRUCTURE OF DROSOPHILA THIOREDOXIN REDUCTASE, C-TERMINAL 8- RESIDUE TRUNCATION
RCSB/PDB
Inspect Structure
See all 3D Structures for Trxr-1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
596P91938-1
508P91938-3
491P91938-2
491P91938-4

Sub-cellular localization


UniProt: Trxr-1 is active in the following subcellular-locations: cytoplasm, mitochondrion.
GO terms: Trxr-1 is active in the following subcellular-locations: cytoplasm, cytosol, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Trxr-1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Trxr-1 there are:
3 structures (5 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Trxr-1 has been screened with compounds ( bioactivities). (see details)