Molecular Target Synopsis
Overview
Domains and Structures
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Druggability
Chemistry
Ligand Efficiency Plot
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(P84902) - Overview - Molecular Target Synopsis

Protein


, Cassiicolin
UniProt P84902

Also Known as CASSI_CORCC

Toxin, essential for pathogenicity. Causes symptoms of Corynespora leaf fall disease (CLF) in rubber trees, including chlorosis, development of brown spots and necrosis. Alters leaf cell ultrastructure, causing plasmolysis in most cell types. In extreme cases the plasmolysis leads to disruption of the plasma membrane. Also affects chloroplast structure, causing lamellae distortion and reduced thylakoids stacking together. Causes accumulation of starch grains. Does not affect the nucleus or mitochondria. Toxic to N.tabacum, L.esculentum, S.ionantha, F.lyrata, P.violacea, S.melongena, and G.max. Not toxic to P.alba, G.hirsutum, P.acerifolia, R.pseudoacacia, T.zebrina, M.alba, and Q.ilex.

2HGO
26 RESIDUE FRAGMENT OF
CASSIICOLIN
IN THE STRUCTURE OF
NMR STRUCTURE OF CASSIICOLIN
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
27P84902-1

Sub-cellular localization


UniProt: is active in the following subcellular-locations: secreted.
GO terms: is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis