Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

aauB (P84888) - Overview - Molecular Target Synopsis

Protein


aauB, Aralkylamine dehydrogenase heavy chain
Enzyme Classification 1.4.9.2
UniProt P84888

Also Known as AAUB_ALCFA, aauB

Oxidizes primary aromatic amines and, more slowly, some long-chain aliphatic amines, but not methylamine or ethylamine. Uses azurin as an electron acceptor to transfer electrons from the reduced tryptophylquinone cofactor. Heterotetramer of two light and two heavy chains. Binds two azurin molecules per heterotetramer.

2HKR
STRUCTURES OF THE CARBINOLAMINE AND SCHIFF-BASE INTERMEDIATES IN THE REDUCTIVE HALF-REACTION OF AROMATIC AMINE DEHYDROGENASE (AADH) WITH P-METHOXYPHENYLETHYLAMINE
RCSB/PDB
Inspect Structure
See all 3D Structures for aauB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
390P84888-1

Sub-cellular localization


UniProt: aauB is active in the following subcellular-locations: periplasm.
GO terms: aauB is active in the following subcellular-locations: periplasmic space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project aauB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For aauB there are:
27 structures (55 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis