Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

aauA (P84887) - Overview - Molecular Target Synopsis

Protein


aauA, Aralkylamine dehydrogenase light chain
Enzyme Classification 1.4.9.2
UniProt P84887

Also Known as AAUA_ALCFA, aauA

Oxidizes primary aromatic amines and, more slowly, some long-chain aliphatic amines, but not methylamine or ethylamine. Uses azurin as an electron acceptor to transfer electrons from the reduced tryptophylquinone cofactor. Heterotetramer of two light and two heavy chains. Binds two azurin molecules per heterotetramer.

2HKR
STRUCTURES OF THE CARBINOLAMINE AND SCHIFF-BASE INTERMEDIATES IN THE REDUCTIVE HALF-REACTION OF AROMATIC AMINE DEHYDROGENASE (AADH) WITH P-METHOXYPHENYLETHYLAMINE
RCSB/PDB
Inspect Structure
See all 3D Structures for aauA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
182P84887-1

Sub-cellular localization


UniProt: aauA is active in the following subcellular-locations: periplasm.
GO terms: aauA is active in the following subcellular-locations: periplasmic space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project aauA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For aauA there are:
27 structures (54 chains) solved
27 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

aauA is solved in complex with the approved drug(s):

BEZ/BENZOIC ACID (2OK6_D, 2OK6_H).

(see details)
Molecular Target 3D Synopsis