Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(P84801) - Overview - Molecular Target Synopsis

Protein


, Griffithsin
UniProt P84801

Also Known as GRFIN_GRISQ

Mixed specificity lectin with anti-HIV activity. Binds to HIV envelope glycoproteins, including exterior membrane glycoprotein gp120, and inhibits viral entry into cells. Binding to gp120 is dependent on gp120 being glycosylated, and is inhibited by mannose, glucose and N-acetylglucosamine.

3LKY
MONOMERIC GRIFFITHSIN WITH A SINGLE GLY-SER INSERTION
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
121P84801-1

Sub-cellular localization


GO terms: is active in the following subcellular-locations: cell.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
13 structures (21 chains) solved
8 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

is solved in complex with the approved drug(s):

BGC/DEXTROSE (2HYR_A, 2HYR_B, 2NUO_A, 2NUO_B).

(see details)
Molecular Target 3D Synopsis