, Alpha-toxin OD1
Also Known as
Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels. The toxin affect mammalian sodium channels Nav1.7/SCN9A (EC(50)=4.5 nM), Nav1.4/SCN4A (EC(50)=9.6 nM), Nav1.6/SCN8A (EC(50)=30 nM), Nav1.5/SCN5A (only at micromolar concentrations), and insect sodium channel para/tipE (EC(50)=80 nM) (PubMed:16038905, PubMed:16641312, PubMed:23527544). In vivo, intraplantar administration of this toxin elicits pain behaviors, including licking and flinching of the hind paw (PubMed:26999206).