Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

H3F3A,H3F3B (P84243) - Overview - Molecular Target Synopsis

Protein


H3F3A,H3F3B, Histone H3.3
UniProt P84243

Also Known as H33_HUMAN, H3F3A,H3F3B, H3.3A, H3F3, H3.3B

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA, a chaperone required for its incorporation into nucleosomes. Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3).

6INQ
RNA POLYMERASE II ELONGATION COMPLEX STALLED AT SHL(-1) OF THE NUCLEOSOME, WITH FOREIGN DNA (+1 POSITION)
RCSB/PDB
Inspect Structure
See all 3D Structures for H3F3A,H3F3B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: H3F3A,H3F3B is active in the following subcellular-locations: chromosome, nucleus.
GO terms: H3F3A,H3F3B is active in the following subcellular-locations: extracellular exosome, extracellular region, nuclear chromosome, nuclear chromosome, nuclear nucleosome, nucleoplasm, nucleosome, nucleus, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project H3F3A,H3F3B has gain in 6 cell-lines, loss in 0 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)

3D Structures


For H3F3A,H3F3B there are:
60 structures (98 chains) solved
16 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis