Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RHOG (P84095) - Overview - Molecular Target Synopsis

Protein


RHOG, Rho-related GTP-binding protein RhoG
UniProt P84095

Also Known as RHOG_HUMAN, RHOG, ARHG

Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. Interacts with ARHGEF26. Interacts with ARHGEF16.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: RHOG is active in the following subcellular-locations: cell membrane.
GO terms: RHOG is active in the following subcellular-locations: cell cortex, cell projection, cytoplasm, cytosol, endoplasmic reticulum membrane, extracellular exosome, focal adhesion, plasma membrane, secretory granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RHOG has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, MOLT_4, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, HEp-2, SKM-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, IMR-90, HMEC

(see details)

3D Structures


At greater than 50% identity similarity to RHOG there are:
145 structures (250 chains) solved
113 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

RHOG is solved in complex with the approved drug(s):

FMN/RIBOFLAVIN 5'-PHOSPHATE (2WKP_A, 2WKQ_A, 2WKR_A),
AMP/ADENOSINE PHOSPHATE (4ITR_C, 4ITR_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RHOG has been screened with compounds ( bioactivities). (see details)