Molecular Target Synopsis
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petC (P83794) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed11
Chains with at least one site assessed as druggable using the strict criteria3
Chains with at least one site assessed as druggable using the relaxed criteria9


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1VF5_D Cytochrome b6-f complex iron-sulfur subunit Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 74.2 31.9 Yes Yes
2 empty 1.88 57.6 27.8 No No
3 empty 1.88 69.3 9.5 No No
4 empty 2.23 67.2 9.6 No No
5 empty 2.04 65.2 12.6 No No
6 empty 2.21 69.9 9.2 No No
7 empty 1.95 53.7 14.4 No No
8 empty 1.33 49.7 8.8 No No
9 empty 2.37 53.9 11.4 No No
10 empty 2.29 69.2 7.4 No No
1VF5_Q Cytochrome b6-f complex iron-sulfur subunit No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 63.9 22.2 No No
2 empty 1.95 73.6 21.6 No No
3 empty 1.92 53.5 15.5 No No
4 empty 1.76 64.7 13.1 No No
5 empty 1.67 66.8 10.2 No No
6 empty 1.93 48.2 14.8 No No
7 empty 2.42 66.7 12.2 No No
8 empty 1.77 59.4 12.6 No No
9 empty 1.8 71.1 12.3 No No
10 empty 1.86 51.9 13.6 No No
4H13_D Cytochrome b6-f complex iron-sulfur subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 56.6 27.7 Yes No
2 empty 1.79 63.8 16.3 No No
3 empty 2.26 64.3 21 No No
4 empty 2.1 72.8 11 No No
5 empty 1.98 53.7 15.9 No No
6 empty 1.55 66.4 9.6 No No
7 empty 1.65 81.1 0 No No
8 empty 2.6 59.1 8.9 No No
9 empty 2.26 63.8 8.7 No No
10 empty 1.63 56.4 9.4 No No
4I7Z_D Cytochrome b6-f complex iron-sulfur subunit No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 54 14.8 No No
2 empty 1.85 57 12.5 No No
3 empty 3.25 52 7.5 No No
4 empty .72 60.8 8 No No
5 empty 1.2 43 6.8 No No
6 empty 2.33 59.8 6.1 No No
2E76_D Cytochrome b6-f complex iron-sulfur subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 58.9 29.9 Yes No
2 empty 2.44 64.9 20.7 No No
3 empty 1.91 68.8 14 No No
4 empty 2.09 67 10 No No
5 empty 1.59 65.6 9.8 No No
6 empty 1.46 87.6 0 Yes No
7 empty 1.98 49.7 8.2 No No
8 empty 1.78 55.6 13.1 No No
9 empty 1.82 64.9 9.3 No No
10 empty 1.83 55.4 10 No No
2E75_D Cytochrome b6-f complex iron-sulfur subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 59.9 33 Yes No
2 empty 2.31 67.6 27.5 No No
3 empty 1.98 66.4 17 No No
4 empty 2.12 69.5 15.3 No No
5 empty 2.36 62.9 10.3 No No
6 empty 1.74 46.8 10.5 No No
7 empty 2.54 60.9 9.1 No No
8 empty 3.21 54.3 8.9 No No
9 empty 1.88 55.8 9.1 No No
10 empty 2.06 72.1 7.5 No No
4PV1_D Cytochrome b6-f complex iron-sulfur subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 62.2 25.6 Yes No
2 empty 2.23 58.9 18.2 No No
3 empty 2.15 77 14.1 No No
4 empty 2.01 73.1 15.7 No No
5 empty 1.98 66.4 14.4 No No
6 empty 2.31 68.8 9.9 No No
7 empty 1.76 66.5 8.8 No No
8 empty 1.96 51.7 8.9 No No
9 empty 2.19 53.6 13.2 No No
10 empty 1.88 55.3 9.4 No No
2E74_D Cytochrome b6-f complex iron-sulfur subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 64.6 25.7 Yes No
2 empty 2.09 66.4 22.3 No No
3 empty 2.26 63.9 17.2 No No
4 empty 1.91 52.5 14 No No
5 empty 1.89 75.5 16.6 No No
6 empty 2.08 75.5 12 No No
7 empty 1.8 52.4 16 No No
8 empty 2.3 67.5 12.7 No No
9 empty 2.38 67.8 9.8 No No
10 empty 2.99 50.6 8.9 No No
4H0L_D Cytochrome b6-f complex iron-sulfur subunit Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 54.1 26.2 Yes No
2 empty 2.03 66.5 23.3 No No
3 empty 2.29 62.4 17.1 No No
4 empty 2.21 67.6 15.2 No No
5 empty 1.5 69.9 13 No No
6 empty 2.1 53.7 15 No No
7 empty 2.26 64.9 13.2 No No
8 empty 2.34 68.1 8.4 No No
9 empty 3.18 51.3 8.6 No No
10 empty 2.37 64.6 9.3 No No
2D2C_Q Cytochrome b6-f complex iron-sulfur subunit Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 71 29 Yes Yes
2 empty 2 59.5 22.5 No No
3 empty 1.71 71.5 14.7 No No
4 empty 1.54 63.6 18.2 No No
5 empty 2.13 67.1 19.3 No No
6 empty 2.41 61.7 15.2 No No
7 empty 2.61 54.8 10.6 No No
8 empty 2.09 98.9 0 Yes No
9 empty 2.1 67 11.1 No No
10 empty 1.77 44.1 10.6 No No
2D2C_D Cytochrome b6-f complex iron-sulfur subunit Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 73.1 23.7 Yes Yes
2 empty 1.81 69.4 24 No No
3 empty 2.12 48.6 19.8 No No
4 empty 1.52 61.7 19.7 No No
5 empty 2.27 59.2 19 No No
6 empty 1.55 70 9.7 No No
7 empty 2.28 59.2 10.6 No No
8 empty 2.6 51.8 9.9 No No
9 empty 2.06 99.5 0 Yes No
10 empty 1.78 47.9 11.7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed14
Domains assessed as druggable using the strict criteria3
Domains assessed as druggable using the relaxed criteria6

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1VF5_D (100584) Cytochrome b6-f complex iron-sulfur subunit Single transmembrane helix, ISP transmembrane anchor, ISP transmembrane anchor 3Å No No
1VF5_D (100583) Cytochrome b6-f complex iron-sulfur subunit ISP domain, ISP domain, Rieske iron-sulfur protein (ISP) 3Å Yes Yes
1VF5_Q (100594) Cytochrome b6-f complex iron-sulfur subunit ISP domain, ISP domain, Rieske iron-sulfur protein (ISP) 3Å No No
1VF5_Q (100595) Cytochrome b6-f complex iron-sulfur subunit Single transmembrane helix, ISP transmembrane anchor, ISP transmembrane anchor 3Å No No
2D2C_D (131164) Cytochrome b6-f complex iron-sulfur subunit Single transmembrane helix, ISP transmembrane anchor, ISP transmembrane anchor 3.8Å No No
2D2C_D (131163) Cytochrome b6-f complex iron-sulfur subunit ISP domain, ISP domain, Rieske iron-sulfur protein (ISP) 3.8Å Yes Yes
2D2C_Q (131169) Cytochrome b6-f complex iron-sulfur subunit ISP domain, ISP domain, Rieske iron-sulfur protein (ISP) 3.8Å Yes Yes
2D2C_Q (131170) Cytochrome b6-f complex iron-sulfur subunit Single transmembrane helix, ISP transmembrane anchor, ISP transmembrane anchor 3.8Å No No
2E74_D (132049) Cytochrome b6-f complex iron-sulfur subunit ISP domain, ISP domain, Rieske iron-sulfur protein (ISP) 3Å Yes No
2E74_D (132050) Cytochrome b6-f complex iron-sulfur subunit Single transmembrane helix, ISP transmembrane anchor, ISP transmembrane anchor 3Å No No
2E75_D (132054) Cytochrome b6-f complex iron-sulfur subunit ISP domain, ISP domain, Rieske iron-sulfur protein (ISP) 3.55Å Yes No
2E75_D (132055) Cytochrome b6-f complex iron-sulfur subunit Single transmembrane helix, ISP transmembrane anchor, ISP transmembrane anchor 3.55Å No No
2E76_D (132059) Cytochrome b6-f complex iron-sulfur subunit ISP domain, ISP domain, Rieske iron-sulfur protein (ISP) 3.4Å Yes No
2E76_D (132060) Cytochrome b6-f complex iron-sulfur subunit Single transmembrane helix, ISP transmembrane anchor, ISP transmembrane anchor 3.4Å No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score