Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

petB (P83791) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 10/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 10/09/2019)


Chains assessed11
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria5


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1VF5_N Cytochrome b6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.6 60.2 36.1 Yes No
2 bound .96 60.6 23.5 No No
3 empty 2.05 70.3 21.8 No No
4 bound 1.18 65.3 22.5 No No
5 empty 1.54 61.4 18.2 No No
6 empty 2.35 60.6 17.9 No No
7 empty 1.43 73.6 10.6 No No
8 empty 2.24 51.3 10.5 No No
9 empty 2.52 66.1 8.5 No No
10 empty 1.88 65.5 8.7 No No
4H0L_A Cytochrome b6 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty .9 57.9 23 No No
2 bound 1.61 58.8 23.4 No No
3 empty 1.04 62.6 24.7 No No
4 empty 2.02 64.1 17.2 No No
5 empty 2.28 54.8 16.9 No No
6 bound 2.44 59.2 17.9 No No
7 empty 1.17 71 14.5 No No
8 empty 2.8 72.4 11.1 No No
9 empty 1.74 67.2 11.4 No No
10 empty 2.36 65.5 10.6 No No
2D2C_A Cytochrome b6 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.6 66.3 28.2 Yes Yes
2 empty 1.17 59.7 23.5 No No
3 empty 2.26 61.7 24 No No
4 empty 2.04 68 23.2 No No
5 empty 1.13 67.6 22.1 No No
6 empty 1.84 76.3 20.4 No No
7 empty 2.22 47 11.6 No No
8 empty 1.69 71.9 12.4 No No
9 empty 1.4 54.3 9.1 No No
10 empty 1.99 58.4 12.3 No No
1VF5_A Cytochrome b6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.54 63.2 33.4 Yes No
2 bound 1.02 64.1 24.4 No No
3 empty 1.96 71.8 18.7 No No
4 empty 1.15 63.9 22 No No
5 empty 2.57 64.8 14 No No
6 empty 1.21 63.5 10.1 No No
7 empty 1.51 71.8 9.8 No No
8 empty 2.23 48.6 8.7 No No
9 empty 2.13 68.2 8.6 No No
10 empty 2.07 66.5 8.6 No No
4H13_A Cytochrome b6 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound .84 55.7 22.8 No No
2 empty 1.71 59.3 24.7 No No
3 bound .91 63.4 22.2 No No
4 empty 2.07 61.8 18 No No
5 empty 1.4 68.7 16.7 No No
6 empty 2.19 54.4 18 No No
7 empty 1.71 69.6 8.8 No No
8 empty 2.84 75.9 11.5 No No
9 empty 1.7 67.2 10.2 No No
10 empty .3 66.8 7.3 No No
2E74_A Cytochrome b6 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty .9 59.1 23.5 No No
2 empty 1.81 58.3 23.6 No No
3 empty 1.04 63.5 26.9 No No
4 empty 1.99 66.2 18.2 No No
5 empty 1.29 68.9 19 No No
6 empty 2.29 60.9 14 No No
7 empty 2.74 73.7 11.4 No No
8 empty 1.55 67.6 10.5 No No
9 empty 1.83 59.1 13.9 No No
10 empty 2.23 67.7 8 No No
4PV1_A Cytochrome b6 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound .96 59.9 23.8 No No
2 empty 1.08 63.7 20.7 No No
3 empty 2.1 74.7 23.6 No No
4 bound 1.87 63 15.8 No No
5 bound 2.45 56.7 18 No No
6 empty 1.49 67.6 18.8 No No
7 empty 2.16 55.1 15.9 No No
8 empty 1.71 67.9 11.8 No No
9 empty 1.78 39.5 11.3 No No
10 empty 2.05 60.9 9.2 No No
2D2C_N Cytochrome b6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.67 61.2 36.9 Yes No
2 empty .97 61.3 23.8 No No
3 empty 1.91 70.1 22.8 No No
4 empty 1.14 65.1 22.8 No No
5 empty 1.83 61.6 17.4 No No
6 empty 1.55 76 11.5 No No
7 empty 2.22 60.7 12.3 No No
8 empty 2.18 66.1 8.1 No No
9 empty 2.03 57.8 7.3 No No
10 empty 1.22 99.3 0 Yes No
2E76_A Cytochrome b6 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty .81 57.4 23.1 No No
2 empty 1.03 64.1 23.1 No No
3 empty 1.84 63.4 15.9 No No
4 empty 2.02 58.4 17.7 No No
5 empty 1.65 68.3 10.3 No No
6 empty 1.6 69 9.1 No No
7 empty 2.49 56.3 15.4 No No
8 empty 2.87 72.9 9.9 No No
9 empty 1.64 55.5 10.8 No No
10 empty 1.56 70.3 10.2 No No
2E75_A Cytochrome b6 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty .77 56.5 24.3 Yes No
2 empty 1.05 63.5 25.6 No No
3 bound 1.88 62.7 15.6 No No
4 empty 1.71 63.8 14 No No
5 bound 1.58 53.4 11.6 No No
6 empty 2.14 57.2 14.7 No No
7 empty 1.14 72.2 8.9 No No
8 empty 2.72 71.7 10.7 No No
9 empty 1.56 67.1 11 No No
10 empty 2.44 64.1 9.8 No No
4I7Z_A Cytochrome b6 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 57.9 22.6 No No
2 bound .89 57.9 22.4 No No
3 bound .95 62.2 21.3 No No
4 empty 1.66 76.1 12.5 No No
5 empty 2.23 57.4 17 No No
6 empty 2.56 71 16.5 No No
7 empty 1.52 69.9 17.6 No No
8 empty 1.59 68.4 10.6 No No
9 empty 2.06 63.3 13.1 No No
10 empty 2.2 66.7 8.3 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed7
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria5

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1VF5_A (100578) Cytochrome b6 Heme-binding four-helical bundle, Transmembrane di-heme cytochromes, Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) 3Å Yes No
1VF5_N (100589) Cytochrome b6 Heme-binding four-helical bundle, Transmembrane di-heme cytochromes, Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) 3Å No No
2D2C_A (131161) Cytochrome b6 Heme-binding four-helical bundle, Transmembrane di-heme cytochromes, Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) 3.8Å Yes No
2D2C_N (131167) Cytochrome b6 Heme-binding four-helical bundle, Transmembrane di-heme cytochromes, Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) 3.8Å Yes No
2E74_A (132048) Cytochrome b6 Heme-binding four-helical bundle, Transmembrane di-heme cytochromes, Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) 3Å Yes No
2E75_A (132053) Cytochrome b6 Heme-binding four-helical bundle, Transmembrane di-heme cytochromes, Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) 3.55Å Yes No
2E76_A (132058) Cytochrome b6 Heme-binding four-helical bundle, Transmembrane di-heme cytochromes, Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) 3.4Å No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score