Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RBP5 (P82980) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed6
Chains with at least one site assessed as druggable using the strict criteria6
Chains with at least one site assessed as druggable using the relaxed criteria6


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1GGL_B Retinol-binding protein 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.39 90.3 24.2 Yes Yes
2 empty 2.28 74 14.7 No No
3 empty 2.57 58 20.2 No No
4 empty 2.05 60.5 14.7 No No
5 empty 2.61 62.6 21.9 No No
6 empty 1.86 65.5 14.6 No No
7 empty 2.37 70 10.1 No No
8 empty 2.24 70.4 9.5 No No
9 empty 2.47 68.1 11.9 No No
10 empty 1.87 68 6.4 No No
6E5W_D Retinol-binding protein 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.46 99.5 0 Yes Yes
2 empty 1.96 67.6 13.9 No No
3 empty 2.34 61.1 19.5 No No
4 empty 1.96 60.3 14.7 No No
5 empty 2.31 67.8 9.8 No No
6 empty 2 67.6 10.3 No No
7 empty 2.62 57.8 15.1 No No
8 empty 2.32 62.1 9.5 No No
9 empty 2.43 66 6.6 No No
10 empty 2.26 64 10.8 No No
6E5W_B Retinol-binding protein 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 76.7 32.6 Yes Yes
2 empty 2.01 67.3 14.5 No No
3 empty 2.16 59.8 11.8 No No
4 empty 2.34 58.1 12.6 No No
5 empty 2.42 62.8 9.5 No No
6 empty 2.56 64 9 No No
7 empty 2.8 71.2 8.5 No No
8 empty 2.88 61.5 13.3 No No
9 empty 2.29 73.7 7 No No
10 empty 2.33 76 5.6 No No
6E5W_A Retinol-binding protein 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 88.4 20.6 Yes Yes
2 empty 2.31 61.9 15.4 No No
3 empty 2.17 67.3 14.6 No No
4 empty 2.06 57 15.5 No No
5 empty 2.32 55.2 13.8 No No
6 empty 2.3 59.9 10.8 No No
7 empty 2.7 62.3 9.5 No No
8 empty 2.09 60 7.8 No No
9 empty 2.76 59.8 10.9 No No
10 empty 1.59 73.8 6.6 No No
6E5W_C Retinol-binding protein 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.46 99 0 Yes Yes
2 empty 1.92 59.8 16.6 No No
3 empty 2.3 69.4 14.1 No No
4 empty 2.22 59.8 18.3 No No
5 empty 2.27 57.7 17.1 No No
6 empty 2.2 64.9 11.9 No No
7 empty 1.84 57.8 12.8 No No
8 empty 2.35 58.5 12.5 No No
9 empty 2.05 66.7 10.1 No No
10 empty 2.57 60.5 8.7 No No
1GGL_A Retinol-binding protein 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.36 92.9 21.7 Yes Yes
2 empty 2.08 70.8 15.9 No No
3 empty 2.61 58.6 20.8 No No
4 empty 2.15 64.2 17.4 No No
5 empty 2.27 56.2 14.1 No No
6 empty 2.17 62.7 9.8 No No
7 empty 1.98 65.6 9.1 No No
8 empty 3.05 59.9 8.5 No No
9 empty 2.68 62.6 11 No No
10 empty 2.72 62 11.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria2
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1GGL_B (60485) Retinol-binding protein 5 Lipocalins, Lipocalins, Fatty acid binding protein-like 2.3Å Yes Yes
1GGL_A (60484) Retinol-binding protein 5 Lipocalins, Lipocalins, Fatty acid binding protein-like 2.3Å Yes Yes
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


RBP5 is involved in 3 interactions in the network.


Druggability
Overall Druggability Percentile: 54.17
Druggability for Cancer Therapeutics: 25.74
Druggability for Other Therapeutics: 39.36
Cancer-Associated
Cancer-associated percentile : 20.60
Network Articulation Point
Is RBP5 critical for communication in the network?


Detailed Graph Legend:Help