Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RBP5 (P82980) - Overview - Molecular Target Synopsis

Protein


RBP5, Retinol-binding protein 5
UniProt P82980

Also Known as RET5_HUMAN, RBP5

Intracellular transport of retinol.

6E5W
CRYSTAL STRUCTURE OF HUMAN CELLULAR RETINOL BINDING PROTEIN 3 IN COMPLEX WITH ABNORMAL-CANNABIDIOL (ABN-CBD)
RCSB/PDB
Inspect Structure
See all 3D Structures for RBP5

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RBP5 is active in the following subcellular-locations: cytoplasm.
GO terms: RBP5 is active in the following subcellular-locations: cytoplasm, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RBP5 has gain in 4 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, ACHN, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C3A, NUGC-2, JHH-7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, NHLF, HSMM

(see details)

3D Structures


For RBP5 there are:
2 structures (6 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RBP5 has been screened with compounds ( bioactivities). (see details)