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ampD (P82974) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed16
Chains with at least one site assessed as druggable using the strict criteria8
Chains with at least one site assessed as druggable using the relaxed criteria16


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2Y2E_A 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 67.2 32.6 Yes No
2 empty 2.28 55.9 12.1 No No
3 empty 2.14 60.8 13.5 No No
4 empty 2.69 62.7 14.4 No No
5 empty 1.79 65.3 16.2 No No
6 empty 2.49 58.8 14 No No
7 empty 2.77 69.8 10.7 No No
8 empty 2.46 71.2 9.6 No No
9 empty 1.98 61.9 8 No No
10 empty 2.04 62.8 7.8 No No
2Y2D_C 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.68 68.8 35.5 Yes No
2 empty 2.54 66.2 25.5 No No
3 empty 2.07 63.3 12.1 No No
4 empty 2.24 63.4 17.4 No No
5 empty 2.48 57.8 9.3 No No
6 empty 2.68 66.7 9.3 No No
7 empty 2.67 69.1 7.1 No No
8 empty 2.07 79.7 7.3 No No
9 empty 2.53 53.8 9.4 No No
10 empty 2.32 68.9 8.1 No No
2Y2D_B 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.73 63.7 39.3 Yes No
2 empty 2.32 66.7 15.5 No No
3 empty 2.18 59.6 14.3 No No
4 empty 2.26 67.8 8.7 No No
5 empty 2.95 72.1 7.7 No No
6 empty 2.3 71.2 9.1 No No
7 empty 2.21 66.7 7.8 No No
8 empty 2.12 65.4 7.4 No No
9 empty 2.94 58.3 8.8 No No
10 empty 2.26 62.4 7.1 No No
2Y2C_B 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 68.2 39.6 Yes Yes
2 empty 2.49 68.3 25.7 No No
3 empty 2.22 53 14.2 No No
4 empty 2.46 61.6 16.3 No No
5 empty 2.21 56 10.8 No No
6 empty 2.75 73.6 6.8 No No
7 empty 2.87 62.5 9.8 No No
8 empty 2.25 63.6 8.8 No No
9 empty 2.38 76.1 6.9 No No
10 empty 2.45 58.1 8.4 No No
2Y2E_B 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 68.4 28 Yes Yes
2 empty 2.42 65.7 17.8 No No
3 empty 2.51 61.6 18.3 No No
4 empty 2.23 60.6 12 No No
5 empty 2.28 63.8 12 No No
6 empty 2.3 59.3 13.3 No No
7 empty 2.72 56.9 9.3 No No
8 empty 2.06 66.1 9.1 No No
9 empty 2.78 72.8 7 No No
10 empty 2.2 70.1 6.3 No No
2Y28_C 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 67.8 33.1 Yes Yes
2 empty 2.44 64 14.4 No No
3 empty 2.23 59.7 17.3 No No
4 empty 2.81 61.5 10.3 No No
5 empty 2.4 66.1 12 No No
6 empty 2.82 79.5 9.1 No No
7 empty 2.05 64.8 8.8 No No
8 empty 2.68 68.9 7.7 No No
9 empty 2.47 68.9 9.1 No No
10 empty 2.23 67.4 5.9 No No
2Y2B_A 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 68.4 32.6 Yes No
2 empty 2.53 61.9 14.7 No No
3 empty 2.48 65.7 15.6 No No
4 empty 2.52 59.9 17.2 No No
5 empty 2.2 58 13.2 No No
6 empty 2.39 54.9 10.2 No No
7 empty 2.4 70.4 7.6 No No
8 empty 2.19 65.5 8.7 No No
9 empty 2.29 67.9 6.4 No No
10 empty 2.73 71.7 7.4 No No
2Y2C_A 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 65.1 40.6 Yes No
2 empty 2.36 66.5 16.8 No No
3 empty 2.12 67.3 21.4 No No
4 empty 2.45 59.7 17.6 No No
5 empty 2.28 65.6 11.7 No No
6 empty 2.79 67.5 10.4 No No
7 empty 2.58 72.8 6.6 No No
8 empty 2.25 72.1 6.9 No No
9 empty 2.16 74.2 8 No No
10 empty 2.62 68.6 5.8 No No
2Y2B_B 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 67.7 36.1 Yes Yes
2 empty 2.42 63.4 30.6 No No
3 empty 2.25 60.5 12.5 No No
4 empty 2.36 61.6 17.5 No No
5 empty 2.42 63.5 11.5 No No
6 empty 2.91 66.4 9.1 No No
7 empty 2 77.2 9.4 No No
8 empty 2.68 70.2 10.2 No No
9 empty 2.85 70.8 6.7 No No
10 empty 2.18 64.5 6.1 No No
2Y2E_C 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.59 70.7 28.6 Yes Yes
2 empty 2.52 68.9 16.7 No No
3 empty 2.42 60.9 26.6 No No
4 empty 2.16 54.8 18 No No
5 empty 1.92 64.8 9.6 No No
6 empty 2.6 73.4 7.3 No No
7 empty 2.38 68.9 10.2 No No
8 empty 2.63 69.6 9.5 No No
9 empty 3.09 66.1 9.1 No No
10 empty 2.27 69.2 7 No No
2Y28_B 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 67.1 40.7 Yes No
2 empty 2.44 65.4 15.5 No No
3 empty 2.18 59.4 13.5 No No
4 empty 2.6 66.4 8.6 No No
5 empty 1.99 63.6 7.8 No No
6 empty 2.11 69.6 9.2 No No
7 empty 2.77 71.6 6.8 No No
8 empty 2.19 76 0 No No
9 empty 2.1 59.6 8.3 No No
10 empty 2.6 53.9 11 No No
1J3G_A 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.35 70.3 33.2 Yes Yes
2 empty 2.33 66.9 27.1 No No
3 empty 2.65 66.6 24.7 No No
4 empty 2.34 68.3 21.2 No No
5 empty 2.27 67 15 No No
6 empty 2.45 66.6 13.1 No No
7 empty 2.44 66.1 14.8 No No
8 empty 2.51 62.7 16.5 No No
9 empty 2.06 54.1 10 No No
10 empty 2.44 63.1 10.1 No No
2Y2D_A 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 65.7 33.8 Yes No
2 empty 2.55 69.6 11.5 No No
3 empty 1.98 62.7 9.6 No No
4 empty 2.54 68.9 8.4 No No
5 empty 2.56 61.7 12.8 No No
6 empty 2.51 73.8 6.9 No No
7 empty 2.14 75.3 8.7 No No
8 empty 3.28 54.5 11 No No
9 empty 2.34 69.6 7 No No
10 empty 2.61 63.7 7.6 No No
2Y2C_C 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 68.1 28.8 Yes Yes
2 empty 2.55 66.1 27.9 No No
3 empty 2.4 67.2 20.5 No No
4 empty 2.23 60.2 12.9 No No
5 empty 2.64 70.1 8.8 No No
6 empty 3.05 56 9.3 No No
7 empty 2.27 74.5 8.6 No No
8 empty 2.28 73.1 6.8 No No
9 empty 2.82 63.7 7.6 No No
10 empty 2.22 63.2 5.9 No No
2Y28_A 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 65.7 39.4 Yes No
2 empty 2.44 71.5 15.4 No No
3 empty 2.41 60.8 17.9 No No
4 empty 2.23 64.5 11.1 No No
5 empty 2.63 61.5 9.2 No No
6 empty 2.31 62.6 10.3 No No
7 empty 1.93 58.9 11.7 No No
8 empty 2.27 66.4 11.9 No No
9 empty 2.85 58.8 8.2 No No
10 empty 2.53 79.3 6.6 No No
2Y2B_C 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 70.5 27.2 Yes Yes
2 empty 2.39 58.8 26.2 No No
3 empty 2.39 63.4 19.4 No No
4 empty 2.27 60.7 11.4 No No
5 empty 2.66 61.6 11.5 No No
6 empty 2.74 75 9.7 No No
7 empty 2.08 63.7 7.4 No No
8 empty 2.22 60.6 7.1 No No
9 empty 2.44 67.2 9.1 No No
10 empty 2.66 74.7 7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed6
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria6

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1J3G_A (77075) 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD N-acetylmuramoyl-L-alanine amidase-like, N-acetylmuramoyl-L-alanine amidase-like, N-acetylmuramoyl-L-alanine amidase-like Yes Yes
2Y28_A (3600205) 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD N-acetylmuramoyl-L-alanine amidase-like, N-acetylmuramoyl-L-alanine amidase-like, UNMATCHED 1.8Å Yes No
2Y2B_A (3600206) 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD N-acetylmuramoyl-L-alanine amidase-like, N-acetylmuramoyl-L-alanine amidase-like, UNMATCHED 1.9Å Yes No
2Y2C_A (3600207) 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD N-acetylmuramoyl-L-alanine amidase-like, N-acetylmuramoyl-L-alanine amidase-like, UNMATCHED 1.8Å Yes No
2Y2D_A (3600208) 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD N-acetylmuramoyl-L-alanine amidase-like, N-acetylmuramoyl-L-alanine amidase-like, UNMATCHED 2Å Yes No
2Y2E_A (3600209) 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD N-acetylmuramoyl-L-alanine amidase-like, N-acetylmuramoyl-L-alanine amidase-like, UNMATCHED 2Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score