Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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ampD (P82974) - Overview - Molecular Target Synopsis

Protein


ampD, 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
Enzyme Classification 3.5.1.28
UniProt P82974

Also Known as AMPD_CITFR, ampD

Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha-amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety.

2Y28
CRYSTAL STRUCTURE OF SE-MET AMPD DERIVATIVE
RCSB/PDB
Inspect Structure
See all 3D Structures for ampD

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
187P82974-1

Sub-cellular localization


UniProt: ampD is active in the following subcellular-locations: cytoplasm.
GO terms: ampD is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ampD has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ampD there are:
6 structures (16 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis