Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MET6 (P82610) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed13
Chains with at least one site assessed as druggable using the strict criteria13
Chains with at least one site assessed as druggable using the relaxed criteria13


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3PPF_A 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.73 70.7 58.1 Yes Yes
2 empty 1.96 77.6 31 No No
3 empty 1.64 70.5 35.5 No No
4 empty 2.14 70.6 23.4 No No
5 empty 2.02 69.3 35.9 No No
6 empty 1.88 60.4 17.8 No No
7 empty 1.92 67.2 24.1 No No
8 empty 2.15 65.1 16.5 No No
9 empty 2.27 69.3 18.7 No No
10 empty 2.11 55.1 16.2 No No
4L6O_A 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 68.5 70.4 Yes Yes
2 empty 1.97 75.5 42.1 No No
3 empty 1.59 72.5 19.3 No No
4 empty 1.6 71.4 20.2 No No
5 empty 2.33 71.8 23.1 No No
6 empty 1.89 66.8 29 No No
7 empty 1.87 66.9 23.5 No No
8 empty 1.62 71.7 22 No No
9 empty 2.06 63.8 13.9 No No
10 empty 1.98 64.4 18 No No
3PPH_A 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.49 69.8 54.4 Yes Yes
2 empty 1.93 77.3 38.4 No No
3 empty 1.54 77.8 29.4 No No
4 empty 1.83 62.7 25.6 No No
5 empty 1.61 73.2 18.2 No No
6 empty 2.12 70.4 30 No No
7 empty 2.07 68.7 21.7 No No
8 empty 1.5 70.3 13.6 No No
9 empty 1.57 74.1 18.1 No No
10 empty 2.19 61.5 29.8 No No
4QQU_A 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.34 73.7 65.3 Yes Yes
2 empty 1.99 76.9 35.8 No No
3 empty 1.99 70.4 36.8 No No
4 empty 2.18 69.5 25.6 No No
5 empty 2.2 73.4 33.1 No No
6 empty 1.59 72 22.2 No No
7 empty 2.25 67 25.1 No No
8 empty 1.94 74.6 16.7 No No
9 empty 2.21 66.5 17.5 No No
10 empty 1.38 75.5 16.8 No No
4L64_A 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 69.4 62.9 Yes Yes
2 empty 1.9 75.2 35.8 No No
3 empty 1.69 75.8 29.5 No No
4 empty 1.61 71.2 20.6 No No
5 empty 2.2 69.1 31 No No
6 empty 1.86 67.2 26.8 No No
7 empty 2.23 66.9 25.9 No No
8 empty 1.91 62.5 15.1 No No
9 empty 2.05 72.4 21.9 No No
10 empty 1.99 68.7 16.9 No No
3PPC_A 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.49 69.2 57.6 Yes Yes
2 empty 1.87 75.3 37.5 No No
3 empty 1.97 67.3 30.8 No No
4 empty 2.32 71 36.4 No No
5 empty 1.53 76.9 23.1 No No
6 empty 1.94 65.8 22.6 No No
7 empty 2.24 67.2 22.4 No No
8 empty 1.97 68.7 15.2 No No
9 empty 1.23 98 0 Yes No
10 empty 2.12 75.6 11 No No
3PPH_B 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 72.1 56.3 Yes Yes
2 empty 1.69 78.4 26.9 Yes No
3 empty 2.15 72.2 29.1 No No
4 empty 1.52 73.2 17.6 No No
5 empty 1.83 70.9 16.7 No No
6 empty 1.44 72.8 23.6 No No
7 empty 1.9 60.6 16.4 No No
8 empty 1.52 75.3 13.2 No No
9 empty 2.02 71.2 15.7 No No
10 empty 2.36 66.1 26.5 No No
4L5Z_A 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 67.4 66.7 Yes Yes
2 empty 1.94 75.8 45.5 No No
3 empty 1.53 71.3 38.6 No No
4 empty 2.16 72.4 23.5 No No
5 empty 1.81 64.7 19.6 No No
6 empty 1.79 70 21.1 No No
7 empty 2.18 68.7 25.1 No No
8 empty 1.94 67.8 18 No No
9 empty 1.21 99.3 0 Yes No
10 empty 1.96 61 18.1 No No
3PPC_B 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.64 70.2 55.3 Yes Yes
2 empty 1.85 76.2 45.2 No No
3 empty 1.59 73.7 35.8 No No
4 empty 2.42 70.7 33.9 No No
5 empty 2.18 66.1 29.2 No No
6 empty 1.94 71.6 17.9 No No
7 empty 1.99 67.2 16.2 No No
8 empty 1.63 81.4 15 No No
9 empty 1.95 61.6 18.5 No No
10 empty 1.23 98.7 0 Yes No
4L6H_A 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 69.1 66.7 Yes Yes
2 empty 2.01 75 37.9 No No
3 empty 2.22 68 30.5 No No
4 empty 1.43 72.3 21.1 No No
5 empty 1.93 67 25.4 No No
6 empty 1.79 68.6 22 No No
7 empty 2.11 68.4 15.9 No No
8 empty 2.06 54.3 16.3 No No
9 empty 1.24 99.4 0 Yes No
10 empty 1.9 69.1 14 No No
4L65_A 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 70.8 64.6 Yes Yes
2 empty 1.96 78.7 31.5 Yes Yes
3 empty 1.56 77.9 28.7 No No
4 empty 1.71 73.2 23.6 No No
5 empty 2.21 69.8 31.2 No No
6 empty 2.23 66.4 30.5 No No
7 empty 2.18 71.3 25.6 No No
8 empty 1.88 66 21.4 No No
9 empty 1.9 60.6 14.3 No No
10 empty 2.16 69.3 23.3 No No
3PPG_A 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 75.3 44.5 Yes Yes
2 empty 1.64 64.5 61.9 No No
3 empty 1.58 70.5 45.3 No No
4 empty 1.42 70.1 39.3 No No
5 empty 2.11 68.8 31.4 No No
6 empty 1.67 79.6 20.8 No No
7 empty 2.06 62.9 17.4 No No
8 empty 2.2 64.3 24.7 No No
9 empty 1.92 66.2 21.7 No No
10 empty 2.01 66.6 16.7 No No
4L61_A 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 69.2 69.9 Yes Yes
2 empty 2 76 41.7 No No
3 empty 1.39 74.2 18.2 No No
4 empty 2.31 70.8 28.6 No No
5 empty 1.97 59.4 19.6 No No
6 empty 1.82 70.3 24.1 No No
7 empty 1.83 67.8 15.4 No No
8 empty 2.09 67 17.8 No No
9 empty 1.89 67.4 18.5 No No
10 empty 2.03 68.3 14.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed6
Domains assessed as druggable using the strict criteria6
Domains assessed as druggable using the relaxed criteria6

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3PPC_B (4161602) 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase UNMATCHED, UNMATCHED, UNMATCHED 3PPC 2.2Å Yes Yes
3PPC_A (4124415) 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase UNMATCHED, UNMATCHED, UNMATCHED 3PPC 2.2Å Yes Yes
3PPF_A (4044211) 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase UNMATCHED, UNMATCHED, UNMATCHED 3PPF 2.3Å Yes Yes
3PPG_A (4082292) 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase UNMATCHED, UNMATCHED, UNMATCHED 3PPG 1.98Å Yes Yes
3PPH_B (4181386) 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase UNMATCHED, UNMATCHED, UNMATCHED 3PPH 2.8Å Yes Yes
3PPH_A (4094843) 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase UNMATCHED, UNMATCHED, UNMATCHED 3PPH 2.8Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score