Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MET6 (P82610) - Overview - Molecular Target Synopsis

Protein


MET6, 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Enzyme Classification 2.1.1.14
UniProt P82610

Also Known as METE_CANAL, MET6

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

4QQU
CRYSTAL STRUCTURE OF THE COBALAMIN-INDEPENDENT METHIONINE SYNTHASE ENZYME IN A CLOSED CONFORMATION
RCSB/PDB
Inspect Structure
See all 3D Structures for MET6

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
767P82610-1

Sub-cellular localization


GO terms: MET6 is active in the following subcellular-locations: cell surface, fungal biofilm matrix, fungal-type cell wall, hyphal cell wall, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MET6 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For MET6 there are:
11 structures (13 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis