Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Irs2 (P81122) - Overview - Molecular Target Synopsis

Protein


Irs2, Insulin receptor substrate 2
UniProt P81122

Also Known as IRS2_MOUSE, Irs2

May mediate the control of various cellular processes by insulin. Interacts with PHIP.

3BU3
14 RESIDUE FRAGMENT OF
INSULIN RECEPTOR SUBSTRATE 2
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH IRS2 KRLB PEPTIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for Irs2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1321P81122-1

Sub-cellular localization


UniProt: Irs2 is active in the following subcellular-locations: cytoplasm, cytosol.
GO terms: Irs2 is active in the following subcellular-locations: cytosol, plasma membrane, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Irs2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Irs2 there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Irs2 has been screened with compounds ( bioactivities). (see details)