Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rpsM (P80377) - Overview - Molecular Target Synopsis

Protein


rpsM, 30S ribosomal protein S13
UniProt P80377

Also Known as RS13_THET8, rpsM, rps13

Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome structure it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the top of the two subunits; these bridges are in contact with the A site and P site tRNAs respectively and are implicated in movement during ribosome translocation. Separately contacts the tRNAs in the A and P sites. Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome, contacting protein L5 and the 23S rRNA; these bridges are straddled by the 5S rRNA.

6CAO
STRUCTURE OF THE RIBOSOMAL DECODING COMPLEX AT AMBIENT TEMPERATURE
RCSB/PDB
Inspect Structure
See all 3D Structures for rpsM

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
126P80377-1, P62655-1

Sub-cellular localization


GO terms: rpsM is active in the following subcellular-locations: ribosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rpsM has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rpsM there are:
120 structures (120 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis