Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LCN2 (P80188) - Overview - Molecular Target Synopsis

Protein


LCN2, Neutrophil gelatinase-associated lipocalin
UniProt P80188

Also Known as NGAL_HUMAN, LCN2, HNL, NGAL

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:27780864, PubMed:20581821). Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:27780864). Can also bind siderophores from M.tuberculosis (PubMed:15642259, PubMed:21978368). Monomer (PubMed:7683678, PubMed:1281792). Homodimer; disulfide-linked (PubMed:7683678). Heterodimer; disulfide-linked with MMP9 (PubMed:7683678).

6O5D
PYOCHELIN
RCSB/PDB
Inspect Structure
See all 3D Structures for LCN2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LCN2 is active in the following subcellular-locations: cytoplasmic granule lumen, cytoplasmic vesicle lumen, secreted.
GO terms: LCN2 is active in the following subcellular-locations: cytosol, extracellular exosome, extracellular region, extracellular space, specific granule lumen.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LCN2 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HT29, HCC_2998, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-5, CL-40, CW-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHEK, SK-N-SH, NHLF

(see details)

3D Structures


For LCN2 there are:
52 structures (149 chains) solved
39 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

LCN2 is solved in complex with the approved drug(s):

LOC/COLCHICINE (5NKN_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LCN2 has been screened with 3 compounds (3 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)