Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

hba (P80043) - Overview - Molecular Target Synopsis

Protein


hba, Hemoglobin subunit alpha
UniProt P80043

Also Known as HBA_PSEBE, hba

Involved in oxygen transport from gills to the various peripheral tissues. Hb1 is a heterotetramer of two alpha chains and two beta chains. HbC is a heterotetramer of two alpha chains and two beta-C chains.

4ODC
CRYSTAL STRUCTURE OF TREMATOMUS BERNACCHII HEMOGLOBIN IN A PARTIALLY CYANIDED STATE
RCSB/PDB
Inspect Structure
See all 3D Structures for hba

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
142P80043-1

Sub-cellular localization


GO terms: hba is active in the following subcellular-locations: hemoglobin complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project hba has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For hba there are:
12 structures (19 chains) solved
12 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


hba has been screened with compounds ( bioactivities). (see details)