Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAP1A (P78559) - Overview - Molecular Target Synopsis

Protein


MAP1A, Microtubule-associated protein 1A
UniProt P78559

Also Known as MAP1A_HUMAN, MAP1A, MAP1L

Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with TIAM2. Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MAP1A is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: MAP1A is active in the following subcellular-locations: axon, axon cytoplasm, axon initial segment, cell projection, cytoplasm, cytosol, dendrite, dendritic branch, dendritic microtubule, dendritic shaft, microtubule, microtubule associated complex, neuron projection, neuronal cell body, primary dendrite, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAP1A has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CCRF_CEM, MOLT_4, SF_539

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G122, Hs 895.T, G112

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, BJ

(see details)


Screening and Chemistry


MAP1A has been screened with compounds ( bioactivities). (see details)