Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

BTG2 (P78543) - Overview - Molecular Target Synopsis

Protein


BTG2, Protein BTG2
UniProt P78543

Also Known as BTG2_HUMAN, BTG2, PC3

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. Interacts with PRKCABP (By similarity). Interacts with CNOT7 and CNOT8; indicative for an association with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization.

3DJU
CRYSTAL STRUCTURE OF HUMAN BTG2
RCSB/PDB
Inspect Structure
See all 3D Structures for BTG2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
158ENSG00000159388ENST00000475157, ENST00000290551ENSP00000433553, ENSP00000290551P78543-1

Sub-cellular localization


GO terms: BTG2 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project BTG2 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, IGROV1, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MOLP-2, LP-1, NCI-H929

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHEK, HMEC

(see details)

3D Structures


For BTG2 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


BTG2 has been screened with compounds ( bioactivities). (see details)