Molecular Target Synopsis
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Druggability
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GSTO1 (P78417) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed28
Chains with at least one site assessed as druggable using the strict criteria12
Chains with at least one site assessed as druggable using the relaxed criteria28


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5UEH_A Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.31 70.4 34.3 Yes No
2 bound 2 62.4 24.5 No No
3 empty 1.86 60.8 18.7 No No
4 empty 1.67 56.4 20.3 No No
5 bound 2.3 62.4 17.3 No No
6 empty 2.12 61.7 14.9 No No
7 empty 1.9 63 10.1 No No
8 empty 1.62 63.5 11.7 No No
9 empty 1.92 62.3 7.4 No No
10 empty 2.6 78 7.8 No No
6MHB_A Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 73.3 28.6 Yes No
2 empty 1.8 61 18.8 No No
3 empty 2.01 58.1 20.7 No No
4 empty 1.94 63.6 19.2 No No
5 empty 1.8 61.5 18.5 No No
6 empty 2.12 68 10.7 No No
7 empty 1.94 61.7 12.2 No No
8 empty 2.01 59.4 12.6 No No
9 empty 2.26 55.2 14.5 No No
10 empty 1.99 52.9 12.4 No No
4YQV_B Glutathione S-transferase omega-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.36 71.7 39.8 Yes Yes
2 empty 2.17 64.8 33.9 No No
3 empty 2.11 69.9 18.8 No No
4 empty 1.96 77.1 12.2 No No
5 empty 2.23 74 9.9 No No
6 empty 2.17 58.8 20.1 No No
7 empty 1.8 58.8 17 No No
8 empty 2.43 65.3 11.6 No No
9 empty 2.18 56.4 13.3 No No
10 empty 1.79 68.5 7.7 No No
4YQU_B Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 75.1 26.9 Yes No
2 empty 2.13 66.9 34.5 No No
3 empty 2.18 62.8 24.8 No No
4 empty 2.04 69 20.1 No No
5 empty 2.3 61 21.3 No No
6 empty 1.92 73.9 14.4 No No
7 empty 2.06 64.1 12.5 No No
8 empty 2.08 64.9 12.1 No No
9 empty 1.53 71.7 10.1 No No
10 empty 1.72 55.6 10.6 No No
3VLN_A Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 65.7 38.8 Yes No
2 bound 2.08 64.8 26.4 No No
3 bound 1.97 67.9 16.4 No No
4 bound 2.45 67.2 17.6 No No
5 empty 1.94 60.1 20.5 No No
6 empty 1.94 69.9 15 No No
7 empty 2.23 62.8 13.9 No No
8 empty 2.08 63.9 14.1 No No
9 empty 1.56 70.9 10.6 No No
10 empty 2.03 67.1 7.9 No No
4IS0_A Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.4 70.8 26 Yes No
2 empty 1.84 56.9 22.2 No No
3 bound 1.96 59.1 23.5 No No
4 bound 2.19 68.6 15.6 No No
5 bound 2.33 62.1 19.5 No No
6 empty 2.24 56.9 15.9 No No
7 empty 1.69 56.1 15.1 No No
8 empty 2.24 54.1 16.3 No No
9 empty 2.02 61.7 12.5 No No
10 empty 1.89 69.6 11.8 No No
4YQM_C Glutathione S-transferase omega-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 71.6 42.6 Yes Yes
2 empty 2.07 64 35.2 No No
3 empty 2.16 63.4 26 No No
4 empty 1.92 76.2 18.7 No No
5 empty 2.09 62.9 19.2 No No
6 empty 1.73 71.8 9.5 No No
7 empty 2.23 63.7 12.1 No No
8 empty 2.27 63.5 13.6 No No
9 empty 2.05 53.3 13.5 No No
10 empty 1.74 71.5 10.1 No No
6MHC_A Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 75.6 30.5 Yes No
2 empty 2.08 60.4 21.3 No No
3 empty 2.39 63.9 23 No No
4 empty 2 74.5 15.8 No No
5 empty 1.95 65.4 16.9 No No
6 empty 2.18 66.7 13.8 No No
7 empty 1.78 65.2 17 No No
8 bound 1.74 62.8 15.1 No No
9 empty 2.19 68 9.4 No No
10 empty 2.35 60 13.6 No No
5V3Q_A Glutathione S-transferase omega-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 66.9 42.1 Yes Yes
2 bound 2.05 65.5 24 No No
3 empty 2.04 66.5 24.1 No No
4 bound 2.4 66.5 18.1 No No
5 empty 2.08 62.6 14.4 No No
6 empty 2 58.9 20 No No
7 empty 1.94 79.7 13.1 No No
8 empty 1.61 70.1 11.2 No No
9 empty 2.25 70 10.2 No No
10 empty 2.35 59.7 10 No No
3LFL_B Glutathione S-transferase omega-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 68.2 41.3 Yes Yes
2 empty 2.36 66.4 33.5 No No
3 empty 2.21 66.3 28.4 No No
4 bound 2.45 60.6 28.1 No No
5 empty 2.33 62.4 15.9 No No
6 empty 2.42 70.7 14.3 No No
7 empty 1.82 69.1 13.7 No No
8 empty 2.17 79.5 10.9 No No
9 empty 2.13 66.5 6.2 No No
10 empty 2.36 77 7 No No
1EEM_A Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 68.4 38.8 Yes No
2 empty 2 61.6 34.3 No No
3 bound 2.05 65.8 23.7 No No
4 bound 2.28 62.7 22 No No
5 empty 2.28 61.2 16.3 No No
6 empty 1.79 69.8 12.5 No No
7 empty 1.6 66.7 10.5 No No
8 empty 2.11 65.8 8.9 No No
9 empty 2.37 73.1 8.8 No No
10 empty 1.94 89.8 12.1 Yes No
5YVO_A Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 64.8 39.2 Yes No
2 bound 2.07 63.9 24.3 No No
3 bound 1.76 55.5 20.2 No No
4 bound 2.49 64 18.8 No No
5 empty 2.24 66.8 10 No No
6 empty 1.81 66.8 9.3 No No
7 empty 2.11 67.6 9.6 No No
8 empty 1.6 66.4 9.5 No No
9 empty 1.38 58 10.5 No No
10 empty 2.94 63.6 9 No No
4YQU_A Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 73.5 32.2 Yes No
2 empty 2.13 63.5 31.9 No No
3 empty 2.19 65 33.7 No No
4 empty 2.33 60.6 21.2 No No
5 empty 2.1 62.3 20.1 No No
6 empty 1.87 78 11.8 No No
7 empty 2.12 65.5 12.5 No No
8 empty 1.69 70.7 8.2 No No
9 empty 1.89 57.1 11.2 No No
10 empty 2.64 70.9 8.5 No No
6MHB_B Glutathione S-transferase omega-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.27 66.2 32.6 Yes Yes
2 empty 1.63 70.2 14.3 No No
3 empty 2.07 64.8 19.7 No No
4 empty 1.82 61.8 19.5 No No
5 empty 2.16 58.8 17 No No
6 empty 1.85 60.3 22.3 No No
7 empty 1.72 66 15.8 No No
8 empty 2.52 62.6 10.5 No No
9 empty 2.24 66.7 10.1 No No
10 empty 2.04 63 12.2 No No
4YQM_A Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 77.6 29.9 Yes No
2 empty 1.95 61.7 18.9 No No
3 empty 2.07 64.8 22.2 No No
4 empty 2.03 63.3 24.9 No No
5 empty 1.95 66.2 17.9 No No
6 empty 2.19 61.7 19.6 No No
7 empty 2.03 58.7 15.3 No No
8 empty 1.41 65 11.5 No No
9 empty 2.01 73.6 13.5 No No
10 empty 2.27 65.9 12.6 No No
4YQV_A Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.61 71.3 30.8 Yes No
2 empty 1.81 58.8 18.3 No No
3 empty 1.97 64.7 17.9 No No
4 empty 1.81 58.7 21.1 No No
5 empty 1.91 55.9 15.4 No No
6 empty 1.75 65.2 13.7 No No
7 empty 1.93 74.4 10.6 No No
8 empty 2.1 66.2 9.9 No No
9 empty 2.1 62.8 11.9 No No
10 empty 2.17 69.5 9.9 No No
6MHB_F Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 70.4 33.3 Yes No
2 empty 1.76 62.2 18.7 No No
3 empty 1.97 64.2 14.6 No No
4 empty 1.74 57 18.7 No No
5 empty 1.85 64.3 13.2 No No
6 empty 1.83 68.3 9.4 No No
7 empty 1.27 64.1 11.7 No No
8 empty 2.08 61 11.3 No No
9 empty 1.39 76.3 8.3 No No
10 empty 2.22 59 11.3 No No
6MHB_D Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.5 77.4 28.1 Yes No
2 empty 1.91 64.7 34.3 No No
3 empty 1.64 73.1 16.2 No No
4 empty 1.94 70.3 17.7 No No
5 empty 2.16 66.8 11.6 No No
6 empty 2.16 64.2 19.6 No No
7 empty 2.03 59.8 19.3 No No
8 empty 2.16 58.2 13.7 No No
9 empty 2.24 60.9 7.7 No No
10 empty 1.71 64.7 11.4 No No
3LFL_C Glutathione S-transferase omega-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.59 71.1 36.2 Yes Yes
2 empty 2.11 68.4 27.1 No No
3 empty 2.36 61.3 28.3 No No
4 empty 2.32 70 19.3 No No
5 empty 2.44 62 22.6 No No
6 bound 2.41 56.8 21.7 No No
7 empty 1.31 76.9 13.2 No No
8 empty 2.1 60.5 14.3 No No
9 empty 2.18 70.8 11.6 No No
10 empty 2.02 67.9 11.5 No No
6MHB_E Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 64.7 34.8 Yes No
2 bound 1.61 74.2 21.4 Yes No
3 empty 1.71 73.1 21.1 No No
4 empty 1.89 67.9 17.8 No No
5 empty 1.9 67.3 20 No No
6 empty 2.23 62.2 18.4 No No
7 empty 1.92 74.1 10.6 No No
8 empty 2.23 68.8 10.8 No No
9 empty 1.99 65.7 9.2 No No
10 empty 1.71 60.1 10.5 No No
4YQV_C Glutathione S-transferase omega-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.44 72.3 30.8 Yes Yes
2 empty 1.9 60.4 17.2 No No
3 empty 1.99 66.3 14 No No
4 empty 2.1 57.8 17.4 No No
5 empty 1.78 55.4 16 No No
6 empty 2.14 60.4 12.3 No No
7 empty 2.13 62.2 11.5 No No
8 empty 1.48 68.8 10.7 No No
9 empty 1.51 67.2 9.2 No No
10 empty 1.87 60.4 12.1 No No
6MHB_C Glutathione S-transferase omega-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 74.6 38.5 Yes Yes
2 empty 1.84 65.9 23.3 No No
3 empty 1.98 74.1 12 No No
4 empty 1.65 65 16.9 No No
5 empty 2.09 62.9 20.2 No No
6 empty 2.23 61.2 13.3 No No
7 empty 2.04 81 9.3 No No
8 empty 1.55 65 10.4 No No
9 empty 2.04 78.3 9.7 No No
10 empty 1.83 58.6 8.8 No No
5YVN_A Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.42 70.5 26.3 Yes No
2 bound 2.04 66 27.6 No No
3 empty 2.23 58.9 20.1 No No
4 bound 2.51 60.6 22.8 No No
5 empty 1.92 63.8 17.1 No No
6 empty 2.11 68.1 14.9 No No
7 empty 2.07 61 20.3 No No
8 empty 2.2 66.5 12 No No
9 empty 2.27 62.9 17.5 No No
10 empty 2.28 78.1 14.3 No No
3LFL_A Glutathione S-transferase omega-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 72.7 40.4 Yes Yes
2 empty 2.12 65.5 26.5 No No
3 empty 2.12 60.2 22.8 No No
4 empty 2.38 63.3 17.8 No No
5 empty 1.92 71.3 17 No No
6 empty 2.12 69.5 15.4 No No
7 empty 2.15 62.5 18.8 No No
8 empty 1.95 63.8 11.7 No No
9 bound 2.5 64.5 15.1 No No
10 empty 1.55 68.5 9.2 No No
4YQM_B Glutathione S-transferase omega-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 71.7 37.6 Yes Yes
2 empty 1.88 65.4 32.5 No No
3 empty 2.1 63.7 26.9 No No
4 empty 2.15 61.5 15.7 No No
5 empty 1.9 74.5 12.3 No No
6 empty 1.6 64.9 8.7 No No
7 empty 1.79 72 6 No No
8 empty 2.17 60.3 10.1 No No
9 empty 2.74 81.1 10.9 No No
10 empty 2.04 55.9 9.1 No No
6MHD_A Glutathione S-transferase omega-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 69.9 42.9 Yes Yes
2 empty 2.05 66.2 33.7 No No
3 empty 2.07 60.9 21.7 No No
4 empty 2.13 75.9 15 No No
5 empty 2.07 63.6 19.3 No No
6 empty 1.84 65.1 14.6 No No
7 empty 2.34 64.3 12.4 No No
8 empty 2.26 67.7 12.9 No No
9 empty 1.36 68.9 8.1 No No
10 empty 2.37 69.4 9.6 No No
6MHC_B Glutathione S-transferase omega-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 71.9 41.1 Yes Yes
2 empty 2.39 66.4 18.1 No No
3 empty 2.16 79.5 13.8 No No
4 empty 2.26 64.8 26.3 No No
5 empty 2.19 62.9 20 No No
6 empty 1.79 64.2 15.3 No No
7 empty 2.36 62.7 15.5 No No
8 bound 1.55 63.6 16.9 No No
9 empty 1.73 72.5 8.6 No No
10 empty 2.52 71.9 8.3 No No
6MHD_B Glutathione S-transferase omega-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 74.1 26.2 Yes No
2 empty 2.08 62.7 24.1 No No
3 empty 1.79 63 18.7 No No
4 empty 1.92 64.2 21.6 No No
5 empty 1.88 72.1 15.2 No No
6 empty 2.05 65 14.7 No No
7 empty 2.18 65 19.3 No No
8 empty 2.34 60.7 13.6 No No
9 empty 2.01 66.7 9 No No
10 empty 2.47 57.4 10.9 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed5
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria5

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1EEM_A (17717) Glutathione S-transferase omega-1 GST C-terminal domain-like, GST C-terminal domain-like, Glutathione S-transferase (GST) C-terminal domain 2Å Yes No
1EEM_A (33011) Glutathione S-transferase omega-1 Thioredoxin fold, Thioredoxin-like, Glutathione S-transferase (GST) N-terminal domain 2Å Yes No
3LFL_B (4158385) Glutathione S-transferase omega-1 GST C-terminal domain-like, GST C-terminal domain-like, Glutathione S-transferase (GST) C-terminal domain (Homo Multimer) 2.1Å Yes Yes
3LFL_A (3630001) Glutathione S-transferase omega-1 GST C-terminal domain-like, GST C-terminal domain-like, UNMATCHED 2.1Å Yes No
3LFL_C (4158385) Glutathione S-transferase omega-1 GST C-terminal domain-like, GST C-terminal domain-like, Glutathione S-transferase (GST) C-terminal domain (Homo Multimer) 2.1Å Yes Yes
3LFL_A (3621000) Glutathione S-transferase omega-1 Thioredoxin fold, Thioredoxin-like, UNMATCHED 2.1Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


GSTO1 is involved in 6 interactions in the network.


Druggability
Overall Druggability Percentile: 30.90
Druggability for Cancer Therapeutics: 40.51
Druggability for Other Therapeutics: 4.10
Cancer-Associated
Cancer-associated percentile : 52.86
Network Articulation Point
Is GSTO1 critical for communication in the network?


Detailed Graph Legend:Help