Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTO1 (P78417) - Overview - Molecular Target Synopsis

Protein


GSTO1, Glutathione S-transferase omega-1
Enzyme Classification 2.5.1.18
UniProt P78417

Also Known as GSTO1_HUMAN, GSTO1, GSTTLP28

Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Homodimer.

6MHD
GLUTATHIONE S-TRANSFERASE OMEGA 1 BOUND TO COVALENT INHIBITOR 44
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTO1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GSTO1 is active in the following subcellular-locations: cytoplasm, cytosol.
GO terms: GSTO1 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTO1 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, MALME_3M, UACC_257

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, 928 mel, SK23

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, NHEK

(see details)

3D Structures


For GSTO1 there are:
14 structures (28 chains) solved
14 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

GSTO1 is solved in complex with the approved drug(s):

ASC/ASCORBIC ACID (3VLN_A),
GDS/OXIGLUTATIONE (4IS0_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTO1 has been screened with 6 compounds (6 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (2 bioactivities). (see details)