ABCA4 (P78363) - Overview - Molecular Target Synopsis
ABCA4, Retinal-specific ATP-binding cassette transporter
Also Known as ABCA4_HUMAN, ABCA4, ABCR
In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
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UniProt: ABCA4 is active in the following subcellular-locations: membrane.
GO terms: ABCA4 is active in the following subcellular-locations: integral component of plasma membrane, intracellular membrane-bounded organelle, membrane, photoreceptor disc membrane.