Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

dsbG (P77202) - Overview - Molecular Target Synopsis

Protein


dsbG, Thiol:disulfide interchange protein DsbG
UniProt P77202

Also Known as DSBG_ECOLI, dsbG, ybdP

Involved in disulfide bond formation. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins such as ErfK, YbiS and YnhG. Probably also functions as a disulfide isomerase with a narrower substrate specificity than DsbC. DsbG is maintained in a reduced state by DsbD. Displays chaperone activity in both redox states in vitro. Homodimer. Interacts with ErfK, YbiS and YnhG.

5G1L
A DOUBLE MUTANT OF DSBG ENGINEERED FOR DENITROSYLATION
RCSB/PDB
Inspect Structure
See all 3D Structures for dsbG

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
248P77202-1

Sub-cellular localization


UniProt: dsbG is active in the following subcellular-locations: periplasm.
GO terms: dsbG is active in the following subcellular-locations: periplasmic space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project dsbG has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For dsbG there are:
8 structures (16 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis