Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

purL (P74881) - Overview - Molecular Target Synopsis

Protein


purL, Phosphoribosylformylglycinamidine synthase
Enzyme Classification 6.3.5.3
UniProt P74881

Also Known as PUR4_SALTY, purL

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. Monomer.

4R7G
DETERMINATION OF THE FORMYLGLYCINAMIDE RIBONUCLEOTIDE AMIDOTRANSFERASE AMMONIA PATHWAY BY COMBINING 3D-RISM THEORY WITH EXPERIMENT
RCSB/PDB
Inspect Structure
See all 3D Structures for purL

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1295P74881-1

Sub-cellular localization


UniProt: purL is active in the following subcellular-locations: cytoplasm.
GO terms: purL is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project purL has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For purL there are:
8 structures (8 chains) solved
8 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis