Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

arsC (P74313) - Overview - Molecular Target Synopsis

Protein


arsC, Glutaredoxin arsenate reductase
Enzyme Classification 1.20.4.1
UniProt P74313

Also Known as ARSC_SYNY3, arsC

Reduces arsenate [As(V)] to arsenite [As(III)] using glutathione and glutaredoxin as sources of reducing equivalents. GrxA is the most effective electron donor in vivo compared to other glutaredoxins. Constitutes the major arsenate reductase compared to ArsI1 and ArsI2. Also shows weak phosphatase activity toward p-nitrophenyl phosphate. Homodimer.

2MYN
AN ARSENATE REDUCTASE IN REDUCED STATE
RCSB/PDB
Inspect Structure
See all 3D Structures for arsC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
131P74313-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project arsC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For arsC there are:
7 structures (7 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis