Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
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Nup54 (P70582) - Overview - Molecular Target Synopsis

Protein


Nup54, Nuclear pore complex protein Nup54
UniProt P70582

Also Known as NUP54_RAT, Nup54

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUP58. Interacts with NUTF2.

4J3H
RING CYCLE FOR DILATING AND CONSTRICTING THE NUCLEAR PORE: STRUCTURE OF A NUP54 HOMO-TETRAMER.
RCSB/PDB
Inspect Structure
See all 3D Structures for Nup54

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
510P70582-1

Sub-cellular localization


UniProt: Nup54 is active in the following subcellular-locations: nuclear pore complex, nucleus, nucleus membrane.
GO terms: Nup54 is active in the following subcellular-locations: nuclear envelope, nuclear membrane, nuclear pore, nuclear pore central transport channel, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Nup54 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Nup54 there are:
3 structures (5 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis