Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HBA1,HBA2 (P69905) - Overview - Molecular Target Synopsis

Protein


HBA1,HBA2, Hemoglobin subunit alpha
UniProt P69905

Also Known as HBA_HUMAN, HBA1,HBA2

Involved in oxygen transport from the lung to the various peripheral tissues. Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA); two alpha chains and two delta chains in adult hemoglobin A2 (HbA2); two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two alpha chains and two gamma chains in fetal hemoglobin F (HbF).

6NBC
HUMAN METHEMOGLOBIN STATE 1 DETERMINED USING SINGLE-PARTICLE CRYO-EM AT 200 KEV
RCSB/PDB
Inspect Structure
See all 3D Structures for HBA1,HBA2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project HBA1,HBA2 has gain in 0 cell-lines, loss in 6 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)

3D Structures


For HBA1,HBA2 there are:
262 structures (529 chains) solved
262 are solved in complex with at least one small molecule ligand
5 are solved with an approved drug

HBA1,HBA2 is solved in complex with the approved drug(s):

PEM/BEZAFIBRATE (5X2S_I, 5X2T_I),
FRU/FRUCTOSE (3B75_A, 3B75_E, 5HY8_A, 5HY8_C),
MET/METHIONINE (1ABW_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HBA1,HBA2 has been screened with 142 compounds (699 bioactivities). (see details)