Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ISPD (P69834) - Overview - Molecular Target Synopsis

Protein


ISPD, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic
Enzyme Classification 2.7.7.60
UniProt P69834

Also Known as ISPD_ARATH, ISPD, MCT, MECT, MEPCT

Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Is essential for chloroplast development and required for pigments and gibberellins biosynthesis.

5MRN
ARABIDOPSIS THALIANA ISPD GLU258ALA MUTANT
RCSB/PDB
Inspect Structure
See all 3D Structures for ISPD

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
302P69834-1

Sub-cellular localization


UniProt: ISPD is active in the following subcellular-locations: chloroplast stroma, plastid.
GO terms: ISPD is active in the following subcellular-locations: chloroplast, chloroplast stroma.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ISPD has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ISPD there are:
13 structures (13 chains) solved
11 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ISPD has been screened with 4 compounds (5 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)