Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
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tatA (P69428) - Overview - Molecular Target Synopsis

Protein


tatA, Sec-independent protein translocase protein TatA
UniProt P69428

Also Known as TATA_ECOLI, tatA, mttA1, yigT

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. A complex containing only TatA and TatB has also been identified. It could be either an assembly intermediate or a disassembly intermediate generated during translocation activity. Each of TatA, TatB and TatC are able to interact in pairs without the third partner; TatA also forms homooligomers.

2MN6
SOLUTION STRUCTURE OF DIMERIC TATA OF TWIN-ARGININE TRANSLOCATION SYSTEM FROM E. COLI
RCSB/PDB
Inspect Structure
See all 3D Structures for tatA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: tatA is active in the following subcellular-locations: cell inner membrane.
GO terms: tatA is active in the following subcellular-locations: cytosol, integral component of membrane, integral component of plasma membrane, TAT protein transport complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project tatA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For tatA there are:
4 structures (13 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis