Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rplY (P68919) - Overview - Molecular Target Synopsis

Protein


rplY, 50S ribosomal protein L25
UniProt P68919

Also Known as RL25_ECOLI, rplY

This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Binds to the 5S rRNA independently of L5 and L18. Not required for binding of the 5S rRNA/L5/L18 subcomplex to 23S rRNA. Part of the 50S ribosomal subunit (PubMed:1093874, PubMed:1100506, Ref.4, PubMed:10094780, PubMed:10756104, PubMed:12809609, PubMed:16272117, PubMed:25310980, PubMed:24844575, PubMed:27934701, PubMed:27906160, PubMed:27906161); part of the 5S rRNA/L5/L18/L25 subcomplex (PubMed:354687, PubMed:8925931). Contacts the 5S rRNA (PubMed:3298242, PubMed:10562563, PubMed:10696113).

6QUL
STRUCTURE OF A BACTERIAL 50S RIBOSOMAL SUBUNIT IN COMPLEX WITH THE NOVEL QUINOXOLIDINONE ANTIBIOTIC CADAZOLID
RCSB/PDB
Inspect Structure
See all 3D Structures for rplY

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: rplY is active in the following subcellular-locations: cytosol, cytosolic large ribosomal subunit.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rplY has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rplY there are:
26 structures (26 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis