Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HBB (P68871) - Overview - Molecular Target Synopsis

Protein


HBB, Hemoglobin subunit beta
UniProt P68871

Also Known as HBB_HUMAN, HBB

Involved in oxygen transport from the lung to the various peripheral tissues., LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure., Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA). Heterotetramer of two zeta chains and two beta chains in hemoglobin Portland-2, detected in fetuses and neonates with homozygous alpha-thalassemia.

6NBC
HUMAN METHEMOGLOBIN STATE 1 DETERMINED USING SINGLE-PARTICLE CRYO-EM AT 200 KEV
RCSB/PDB
Inspect Structure
See all 3D Structures for HBB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
147ENSG00000244734ENST00000335295ENSP00000333994P68873-1, P68871-1, P68872-1
97ENSG00000244734ENST00000380315ENSP00000369671

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project HBB has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, HL_60, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KU812, SET-2, MOLM-16

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD34-positive mobilized cell, CD20-positive B cell, SK-N-SH

(see details)

3D Structures


For HBB there are:
256 structures (533 chains) solved
255 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

HBB is solved in complex with the approved drug(s):

FRU/FRUCTOSE (5HY8_F).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HBB has been screened with 142 compounds (699 bioactivities). (see details)